Distinguishing mild cognitive impairment from Alzheimer’s disease by increased expression of key circulating microRNAs
نویسندگان
چکیده
1Advanced Genomic Technology, LLC, Louisville, Kentucky, USA. 2Department of Neurology & Neurosurgery, McGill University, Montréal, Québec, Canada. 3Memory Clinic, Jewish General Hospital, Montréal, Québec, Canada. 4Bloomfield Centre for Research in Aging, Lady Davis Institute, Montréal, Québec, Canada. 5Department of Clinical Neurosciences, Jewish General Hospital, Montréal, Québec, Canada. 6Division of Geriatric Medicine of the Jewish General Hospital, Montréal, Québec, Canada.
منابع مشابه
Target Genes of Circulating miR-34c as Plasma Protein Biomarkers of Alzheimer’s Disease and Mild Cognitive Impairment
MicroRNAs repress post-transcriptional expression of a variety of genes, several of which are involved in neurological development and Alzheimer’s disease (AD) pathology. In previous studies, we have shown that plasma miR-34c and miR-34a levels are increased in probable AD patients. In this study, we show that four key gene products silenced by these miRNAs, Onecut homoebox 2 (ONECUT2), B-cell ...
متن کاملIdentification of mild cognitive impairment disease using brain functional connectivity and graph analysis in fMRI data
Background: Early diagnosis of patients in the early stages of Alzheimer's, known as mild cognitive impairment, is of great importance in the treatment of this disease. If a patient can be diagnosed at this stage, it is possible to treat or delay Alzheimer's disease. Resting-state functional magnetic resonance imaging (fMRI) is very common in the process of diagnosing Alzheimer's disease. In th...
متن کاملEffect of Amnesia Mild Cognitive Impairment and Alzheimer’s Diseaseon Recognition Memory of Elderly Peoplein Shiraz Verbal Learning Test: Differences in Recognition Discriminability and Response Bias
Background: Most studies have investigated the effect of brain pathological aging on information recall and recognition memory performance of patients (by using a yes/no procedure), and for this reason, provide a partial picture of memory deficits and other factors involved in recognition memory such as discriminability and response bias are not considered. In this regard, the aim of present st...
متن کاملEvaluation of Extracellular Circulating Human MicroRNA-197 as a Target Biomarker in Patients with Coronary Artery Disease
Background: Coronary Artery Disease (CAD) refers to the reduction or blockage of all or part of the coronary arteries due to the process of atherosclerosis or the presence of a clot. The aim of this study was to investigate the association of serum miR-197 as a diagnostic index in patients with coronary artery disease. Methods: In this study, 100 patients with CAD were selected. Extraction of...
متن کاملSimvastatin Attenuates Hippocampal MMP-9 Expression in the Streptozotocin-Induced Cognitive Impairment
Background: Matrix metalloproteinase-9 (MMP-9) expression has been implicated in molecular mechanisms of neurodegenerative disorders, and its abnormal level has been reported in Alzheimer’s disease (AD). Some protective mechanisms of statins against neurodegeneration might be mediated by the inhibition of MMP-9 expression. Here, we investigated the effect of simvastatin, on the hippocampal MMP-...
متن کامل